Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53300
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
52000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53300
Synonyms:
3-[(5E)-4-keto-5-o-anisylidene-2-thioxo-thiazolidin-3-yl]-N-(3-pyridyl)propionamide | 3-[(5E)-5-[(2-methoxyphenyl)methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-pyridin-3-yl-propanamide | 3-[(5E)-5-[(2-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-pyridin-3-ylpropanamide | 3-[(5E)-5-[(2-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-3-thiazolidinyl]-N-(3-pyridinyl)propanamide | MLS001031537 | SMR000664927 | cid_2286451
Type:
Small organic molecule
Emp. Form.:
C19H17N3O3S2
Mol. Mass.:
399.487
SMILES:
COc1ccccc1\C=C1\SC(=S)N(CCC(=O)Nc2cccnc2)C1=O
Structure:
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