Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM60553
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
46900±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM60553
Synonyms:
MLS000390001 | N-[(5-morpholino-2-thienyl)methyleneamino]carbamic acid tert-butyl ester | N-[(E)-(5-morpholino-2-thienyl)methyleneamino]carbamic acid tert-butyl ester | N-[[5-(4-morpholinyl)-2-thiophenyl]methylideneamino]carbamic acid tert-butyl ester | SMR000259265 | cid_2391626 | tert-butyl N-[(5-morpholin-4-ylthiophen-2-yl)methylideneamino]carbamate
Type:
Small organic molecule
Emp. Form.:
C14H21N3O3S
Mol. Mass.:
311.4
SMILES:
CC(C)(C)OC(=O)NN=Cc1ccc(s1)N1CCOCC1 |w:8.7|
Structure:
Search PDB for entries with ligand similarity: