Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83586
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
72000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83586
Synonyms:
(4Z)-2-(methylthio)-4-[(5-methyl-2-thiophenyl)methylidene]-5-thiazolone | (4Z)-2-methylsulfanyl-4-[(5-methylthiophen-2-yl)methylidene]-1,3-thiazol-5-one | (4Z)-4-[(5-methyl-2-thienyl)methylene]-2-(methylthio)-2-thiazolin-5-one | 4-[(5-methyl-2-thienyl)methylene]-2-(methylthio)-1,3-thiazol-5(4H)-one | MLS000666337 | SMR000271275 | cid_803385
Type:
Small organic molecule
Emp. Form.:
C10H9NOS3
Mol. Mass.:
255.38
SMILES:
CSC1=N\C(=C/c2ccc(C)s2)C(=O)S1 |t:2|
Structure:
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