Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83617
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
10600±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83617
Synonyms:
2,4-dimethyl-3-(2-oxidanylidenepyrrolidin-1-yl)benzenesulfonohydrazide | 2,4-dimethyl-3-(2-oxo-1-pyrrolidinyl)benzenesulfonohydrazide | 2,4-dimethyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonohydrazide | 3-(2-ketopyrrolidino)-2,4-dimethyl-benzenesulfonohydrazide | MLS000777818 | SMR000414206 | cid_3315168
Type:
Small organic molecule
Emp. Form.:
C12H17N3O3S
Mol. Mass.:
283.347
SMILES:
Cc1ccc(c(C)c1N1CCCC1=O)S(=O)(=O)NN
Structure:
Search PDB for entries with ligand similarity: