Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53059
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53059
Synonyms:
2-(7-Nitro-benzo[1,2,5]oxadiazol-4-ylamino)-phenol | 6-[(4-nitro-1,3-dihydro-2,1,3-benzoxadiazol-7-yl)imino]-1-cyclohexa-2,4-dienone | 6-[(4-nitro-1,3-dihydro-2,1,3-benzoxadiazol-7-yl)imino]cyclohexa-2,4-dien-1-one | 6-[(7-nitro-1,3-dihydrobenzofurazan-4-yl)imino]cyclohexa-2,4-dien-1-one | MLS001206694 | SMR000516446 | cid_5719582
Type:
Small organic molecule
Emp. Form.:
C12H8N4O4
Mol. Mass.:
272.2163
SMILES:
[O-]c1ccccc1\N=c1/ccc([N+]([O-])=O)c2[nH]o[nH+]c12
Structure:
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