Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM53161
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM53161
Synonyms:
(3E)-1H-indole-2,3-dione 3-[(3-chlorophenyl)hydrazone] | 3-[(3-chlorophenyl)hydrazo]-2-indolone | 3-[2-(3-chlorophenyl)hydrazinyl]indol-2-one | 3-[N'-(3-chlorophenyl)hydrazino]indol-2-one | MLS001201262 | SMR000564056 | cid_5952111
Type:
Small organic molecule
Emp. Form.:
C14H10ClN3O
Mol. Mass.:
271.702
SMILES:
Clc1cccc(NNC2=c3ccccc3=NC2=O)c1 |c:8,15|
Structure:
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