Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM83823
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59612±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM83823
Synonyms:
2-[[2-keto-2-(2-piperidinoanilino)ethyl]thio]-N-(p-tolyl)acetamide | MLS001079955 | N-(4-methylphenyl)-2-[2-oxidanylidene-2-[(2-piperidin-1-ylphenyl)amino]ethyl]sulfanyl-ethanamide | N-(4-methylphenyl)-2-[2-oxo-2-(2-piperidin-1-ylanilino)ethyl]sulfanylacetamide | N-(4-methylphenyl)-2-[[2-oxo-2-[2-(1-piperidinyl)anilino]ethyl]thio]acetamide | SMR000711942 | cid_24979220
Type:
Small organic molecule
Emp. Form.:
C22H27N3O2S
Mol. Mass.:
397.534
SMILES:
Cc1ccc(NC(=O)CSCC(=O)Nc2ccccc2N2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: