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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM80079
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter
EC50
>59718±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter PubChem Bioassay (2011)[AID] 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
FXN frataxin | PYRF_ASPNG | pyrA | pyrG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
30195.13
Organism:
Aspergillus niger
Description:
gi_2395
Residue:
277
Sequence:
MSSKSQLTYTARASKHPNALAKRLFEIAEAKKTNVTVSADVTTTKELLDLADRLGPYIAVIKTHIDILSDFSDETIEGLKALAQKHNFLIFEDRKFIDIGNTVQKQYHRGTLRISEWAHIINCSILPGEGIVEALAQTASAPDFSYGPERGLLILAEMTSKGSLATGQYTTSSVDYARKYKNFVMGFVSTRSLGEVQSEVSSPSDEEDFVVFTTGVNISSKGDKLGQQYQTPASAIGRGADFIIAGRGIYAAPDPVQAAQQYQKEGWEAYLARVGGN
  
Inhibitor
Name:
BDBM80079
Synonyms:
5-bromanyl-1-[[4-methylidene-5-oxidanylidene-2-(4-phenylphenyl)oxolan-2-yl]methyl]pyrimidine-2,4-dione | 5-bromo-1-[[4-methylene-5-oxo-2-(4-phenylphenyl)-2-oxolanyl]methyl]pyrimidine-2,4-dione | 5-bromo-1-[[4-methylidene-5-oxo-2-(4-phenylphenyl)oxolan-2-yl]methyl]pyrimidine-2,4-dione | 5-bromo-1-[[5-keto-4-methylene-2-(4-phenylphenyl)tetrahydrofuran-2-yl]methyl]pyrimidine-2,4-quinone | MLS002702193 | SMR001565756 | cid_381504
Type:
Small organic molecule
Emp. Form.:
C22H17BrN2O4
Mol. Mass.:
453.285
SMILES:
Brc1cn(CC2(CC(=C)C(=O)O2)c2ccc(cc2)-c2ccccc2)c(=O)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: