Reaction Details Report a problem with these data
Target
Caspase-9
Ligand
BDBM61226
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
IC50
7710±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay (2011)[AID] 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM61226
Synonyms:
3,4-dimethyl-N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide | MLS000830217 | N-(2-hydroxy-1,3-diketo-indan-2-yl)-3,4-dimethyl-benzamide | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-3,4-dimethylbenzamide | N-(2-hydroxy-1,3-dioxo-2-indenyl)-3,4-dimethylbenzamide | N-(2-hydroxy-1,3-dioxoinden-2-yl)-3,4-dimethylbenzamide | SMR000458138 | cid_2810379
Type:
Small organic molecule
Emp. Form.:
C18H15NO4
Mol. Mass.:
309.316
SMILES:
Cc1ccc(cc1C)C(=O)NC1(O)C(=O)c2ccccc2C1=O
Structure:
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