Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83533
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83533
Synonyms:
2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-3-(4-nitrophenyl)-4-quinazolinone | 2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one | 2-[(E)-2-(2-methyl-1H-indol-3-yl)vinyl]-3-(4-nitrophenyl)quinazolin-4-one | 2-[2-(2-methyl-1H-indol-3-yl)vinyl]-3-(4-nitrophenyl)-4(3H)-quinazolinone | MLS000571785 | SMR000193797 | cid_5345959
Type:
Small organic molecule
Emp. Form.:
C25H18N4O3
Mol. Mass.:
422.4354
SMILES:
Cc1[nH]c2ccccc2c1\C=C\c1nc2ccccc2c(=O)n1-c1ccc(cc1)[N+]([O-])=O
Structure:
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