Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83663
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
21800±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83663
Synonyms:
4-[[(2-keto-1,3,3-trimethyl-indolin-5-yl)sulfonylamino]methyl]-N-sec-butyl-benzamide | MLS001124541 | N-butan-2-yl-4-[[(1,3,3-trimethyl-2-oxidanylidene-indol-5-yl)sulfonylamino]methyl]benzamide | N-butan-2-yl-4-[[(1,3,3-trimethyl-2-oxo-5-indolyl)sulfonylamino]methyl]benzamide | N-butan-2-yl-4-[[(1,3,3-trimethyl-2-oxoindol-5-yl)sulfonylamino]methyl]benzamide | SMR000628630 | cid_16019691
Type:
Small organic molecule
Emp. Form.:
C23H29N3O4S
Mol. Mass.:
443.559
SMILES:
CCC(C)NC(=O)c1ccc(CNS(=O)(=O)c2ccc3N(C)C(=O)C(C)(C)c3c2)cc1
Structure:
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