Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83664
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay
EC50
9720±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of the MazEF TA System via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83664
Synonyms:
4-[[(2-keto-1,3,3-trimethyl-indolin-5-yl)sulfonylamino]methyl]-N-[(5-methyl-2-furyl)methyl]benzamide | MLS001124561 | N-[(5-methyl-2-furanyl)methyl]-4-[[(1,3,3-trimethyl-2-oxo-5-indolyl)sulfonylamino]methyl]benzamide | N-[(5-methylfuran-2-yl)methyl]-4-[[(1,3,3-trimethyl-2-oxidanylidene-indol-5-yl)sulfonylamino]methyl]benzamide | N-[(5-methylfuran-2-yl)methyl]-4-[[(1,3,3-trimethyl-2-oxoindol-5-yl)sulfonylamino]methyl]benzamide | SMR000628632 | cid_20903324
Type:
Small organic molecule
Emp. Form.:
C25H27N3O5S
Mol. Mass.:
481.564
SMILES:
CN1C(=O)C(C)(C)c2cc(ccc12)S(=O)(=O)NCc1ccc(cc1)C(=O)NCc1ccc(C)o1
Structure:
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