Reaction Details
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Potassium voltage-gated channel subfamily KQT member 2
Ligand
BDBM84179
Substrate
n/a
Meas. Tech.
Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II
IC50
4813.68±305.28 nM
Citation
PubChem, PC Dose response assay for compounds that inhibit KCNQ2 potassium channels on automated electrophysiological assay II PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
Potassium voltage-gated channel subfamily KQT member 2
Synonyms:
KCNQ2_RAT | Kcnq2 | Voltage-gated potassium channel subunit Kv7.2 | potassium voltage-gated channel, KQT-like subfamily, member 2
Type:
PROTEIN
Mol. Mass.:
93984.01
Organism:
Rattus norvegicus
Description:
EBI_100117
Residue:
852
Sequence:
MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMISSQTQTYGASRLIPPLNQLEMLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRKYAAPPVMPPAECPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNRASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLNALASCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK
Inhibitor
Name:
BDBM84179
Synonyms:
2-bromanyl-N-[2-[(4-methoxyphenyl)amino]phenyl]benzamide | 2-bromo-N-[2-(4-methoxyanilino)phenyl]benzamide | 2-bromo-N-[2-(p-anisidino)phenyl]benzamide | MLS001233685 | SMR000591427 | cid_2403037
Type:
Small organic molecule
Emp. Form.:
C20H17BrN2O2
Mol. Mass.:
397.265
SMILES:
COc1ccc(Nc2ccccc2NC(=O)c2ccccc2Br)cc1
Structure:
