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Target
Meprin A subunit alpha
Ligand
BDBM50240415
Substrate
n/a
Meas. Tech.
ChEMBL_1668163 (CHEMBL4018051)
IC50
3290±n/a nM
Citation
 Ramsbeck, D; Hamann, A; Schlenzig, D; Schilling, S; Buchholz, M First insight into structure-activity relationships of selective meprin? inhibitors. Bioorg Med Chem Lett 27:2428-2431 (2017) [PubMed]  Article 
Target
Name:
Meprin A subunit alpha
Synonyms:
3.4.24.18 | Endopeptidase-2 | MEP1A | MEP1A_HUMAN | Meprin A subunit alpha | N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha | PABA peptide hydrolase | PPH alpha
Type:
PROTEIN
Mol. Mass.:
84405.87
Organism:
Homo sapiens
Description:
ChEMBL_117380
Residue:
746
Sequence:
MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK
  
Inhibitor
Name:
BDBM50240415
Synonyms:
CHEMBL4078433
Type:
Small organic molecule
Emp. Form.:
C17H18N2O7S
Mol. Mass.:
394.399
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: