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Target
5'-AMP-activated protein kinase subunit gamma-2
Ligand
BDBM50246120
Substrate
n/a
Meas. Tech.
ChEMBL_1676495 (CHEMBL4026638)
EC50
118±n/a nM
Citation
 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem 60:9040-9052 (2017) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase subunit gamma-2
Synonyms:
AAKG2_HUMAN | AMPK gamma2 | AMPK subunit gamma-2 | H91620p | PRKAG2
Type:
PROTEIN
Mol. Mass.:
63086.61
Organism:
Homo sapiens
Description:
ChEMBL_117733
Residue:
569
Sequence:
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
  
Inhibitor
Name:
BDBM50246120
Synonyms:
CHEMBL4082745
Type:
Small organic molecule
Emp. Form.:
C27H19ClN2O3
Mol. Mass.:
454.904
SMILES:
Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O
Structure:
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