Reaction Details Report a problem with these data
Target
14-3-3 protein zeta/delta
Ligand
BDBM50454781
Substrate
n/a
Meas. Tech.
ChEMBL_1753374 (CHEMBL4188134)
Kd
9.0±n/a nM
Citation
 Inoue, T; Higuchi, Y; Yoneyama, T; Lin, B; Nunomura, K; Honma, Y; Kato, N Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A. Bioorg Med Chem Lett 28:646-650 (2018) [PubMed]  Article 
Target
Name:
14-3-3 protein zeta/delta
Synonyms:
14-3-3 protein zeta/delta | 1433Z_HUMAN | KCIP-1 | Protein kinase C inhibitor protein 1 | YWHAZ
Type:
PROTEIN
Mol. Mass.:
27731.18
Organism:
Homo sapiens
Description:
ChEMBL_117504
Residue:
245
Sequence:
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
  
Inhibitor
Name:
BDBM50454781
Synonyms:
CHEMBL4206466
Type:
Small organic molecule
Emp. Form.:
C33H50O11
Mol. Mass.:
622.7435
SMILES:
[H][C@]1(CO1)[C@]1(C)O[C@@]23O[C@]1([H])O[C@]2([H])[C@@H](O)[C@@H](O[C@@]1([H])[C@H](O)[C@H](C)[C@]2([H])CC[C@](O)(COC)\C2=C\[C@@]2(C)CCC(C(C)C)=C12)O[C@@H]3COC |r,c:37,t:46|
Structure:
Search PDB for entries with ligand similarity: