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Target
Meprin A subunit alpha
Ligand
BDBM50455682
Substrate
n/a
Meas. Tech.
ChEMBL_1754852 (CHEMBL4189612)
IC50
1795±n/a nM
Citation
 Ramsbeck, D; Hamann, A; Richter, G; Schlenzig, D; Geissler, S; Nykiel, V; Cynis, H; Schilling, S; Buchholz, M Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors. J Med Chem 61:4578-4592 (2018) [PubMed]  Article 
Target
Name:
Meprin A subunit alpha
Synonyms:
3.4.24.18 | Endopeptidase-2 | MEP1A | MEP1A_HUMAN | Meprin A subunit alpha | N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha | PABA peptide hydrolase | PPH alpha
Type:
PROTEIN
Mol. Mass.:
84405.87
Organism:
Homo sapiens
Description:
ChEMBL_117380
Residue:
746
Sequence:
MAWIRSTCILFFTLLFAHIAAVPIKYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILLQKSRNGLRDPNTRWTFPIPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEVDHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKMTGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQKFRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSKGDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWPVENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSPAINDTVIWDRPSRVGTYHTDCNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLSQTEVPTKGKRLSPQGLILQGQEQQVSEEGSGKAMLEEALPVSLSQGQPSRQKRSVENTGPLEDHNWPQYFRDPCDPNPCQNDGICVNVKGMASCRCISGHAFFYTGERCQAVQVHGSVLGMVIGGTAGVIFLTFSIIAILSQRPRK
  
Inhibitor
Name:
BDBM50455682
Synonyms:
CHEMBL4206683
Type:
Small organic molecule
Emp. Form.:
C17H17ClN2O4
Mol. Mass.:
348.781
SMILES:
ONC(=O)CN(Cc1ccc(Cl)cc1)Cc1cccc(c1)C(O)=O
Structure:
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