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Target
Ubiquitin carboxyl-terminal hydrolase 2
Ligand
BDBM50458417
Substrate
n/a
Meas. Tech.
ChEMBL_1763387 (CHEMBL4198634)
IC50
>100000±n/a nM
Citation
 Tomala, MD; Magiera-Mularz, K; Kubica, K; Krzanik, S; Zieba, B; Musielak, B; Pustula, M; Popowicz, GM; Sattler, M; Dubin, G; Skalniak, L; Holak, TA Identification of small-molecule inhibitors of USP2a. Eur J Med Chem 150:261-267 (2018) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2
Synonyms:
41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2
Type:
PROTEIN
Mol. Mass.:
68093.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103660
Residue:
605
Sequence:
MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM50458417
Synonyms:
CHEMBL4203489
Type:
Small organic molecule
Emp. Form.:
C20H17N3O4S
Mol. Mass.:
395.432
SMILES:
CCCn1nc(C(=O)OCc2cc(on2)-c2cccs2)c2ccccc2c1=O
Structure:
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