Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50025710
Substrate
n/a
Meas. Tech.
ChEBML_28519
IC50
3±n/a nM
Citation
 Hamilton, HW; Ortwine, DF; Worth, DF; Bristol, JA Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists. J Med Chem 30:91-6 (1987) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50025710
Synonyms:
3-Ethyl-1-methyl-8-phenyl-3,7-dihydro-purine-2,6-dione | CHEMBL175215
Type:
Small organic molecule
Emp. Form.:
C14H14N4O2
Mol. Mass.:
270.2866
SMILES:
CCn1c2nc([nH]c2c(=O)n(C)c1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: