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Target
Sporulation kinase A
Ligand
BDBM50471716
Substrate
n/a
Meas. Tech.
ChEMBL_37761 (CHEMBL650776)
IC50
27000±n/a nM
Citation
 Macielag, MJ; Demers, JP; Fraga-Spano, SA; Hlasta, DJ; Johnson, SG; Kanojia, RM; Russell, RK; Sui, Z; Weidner-Wells, MA; Werblood, H; Foleno, BD; Goldschmidt, RM; Loeloff, MJ; Webb, GC; Barrett, JF Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem 41:2939-45 (1998) [PubMed]  Article 
Target
Name:
Sporulation kinase A
Synonyms:
KINA_BACSU | Sporulation kinase A | Stage II sporulation protein F | Stage II sporulation protein J | gsiC | kinA | scoD | spoIIF | spoIIJ
Type:
PROTEIN
Mol. Mass.:
69161.05
Organism:
Bacillus subtilis (strain 168)
Description:
ChEMBL_105028
Residue:
606
Sequence:
MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK
  
Inhibitor
Name:
BDBM50471716
Synonyms:
CHEMBL431272
Type:
Small organic molecule
Emp. Form.:
C15H7Cl2F6NO2
Mol. Mass.:
418.118
SMILES:
Oc1c(cc(cc1C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(Cl)c(Cl)c1
Structure:
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