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Target
D(3) dopamine receptor
Ligand
BDBM50474392
Substrate
n/a
Meas. Tech.
ChEMBL_62595 (CHEMBL674272)
Ki
2.0±n/a nM
Citation
 Macdonald, GJ; Branch, CL; Hadley, MS; Johnson, CN; Nash, DJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Austin, NE; Jeffrey, P; Winborn, KY; Boyfield, I; Hagan, JJ; Middlemiss, DN; Reavill, C; Riley, GJ; Watson, JM; Wood, M; Parker, SG; Ashby, CR Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist. J Med Chem 46:4952-64 (2003) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50474392
Synonyms:
CHEMBL3084601
Type:
Small organic molecule
Emp. Form.:
C30H37ClN4O4S
Mol. Mass.:
585.157
SMILES:
Cl.CS(=O)(=O)Oc1ccc2CCN(CC[C@H]3CC[C@@H](CC3)NC(=O)c3cccc(c3)-c3ncccn3)CCc2c1 |r,wU:18.20,wD:15.13,(16.59,,;-11.7,.29,;-12.47,-1.05,;-13.8,-.28,;-13.24,-2.38,;-11.13,-1.82,;-9.8,-1.05,;-9.8,.49,;-8.47,1.26,;-7.13,.49,;-5.93,1.45,;-4.43,1.11,;-3.76,-.28,;-2.22,-.28,;-1.45,-1.61,;.09,-1.61,;.86,-2.94,;2.4,-2.94,;3.17,-1.61,;2.4,-.28,;.86,-.28,;4.71,-1.61,;5.48,-.28,;4.71,1.06,;7.02,-.28,;7.79,-1.61,;9.33,-1.61,;10.1,-.28,;9.33,1.06,;7.79,1.06,;10.1,2.39,;9.33,3.72,;10.1,5.06,;11.64,5.06,;12.41,3.72,;11.64,2.39,;-4.43,-1.66,;-5.93,-2.01,;-7.13,-1.05,;-8.47,-1.82,)|
Structure:
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