Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 8
Ligand
BDBM50370587
Substrate
n/a
Meas. Tech.
ChEMBL_838483 (CHEMBL2076054)
Ki
780000±n/a nM
Citation
 Jung, KY; Takeda, M; Shimoda, M; Narikawa, S; Tojo, A; Kim, DK; Chairoungdua, A; Choi, BK; Kusuhara, H; Sugiyama, Y; Sekine, T; Endou, H Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. Life Sci 70:1861-74 (2002) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 8
Synonyms:
Oat3 | Organic anion transporter 3 | S22A8_RAT | Slc22a8 | rOat3
Type:
PROTEIN
Mol. Mass.:
59199.83
Organism:
Rattus norvegicus
Description:
ChEMBL_1482580
Residue:
536
Sequence:
MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIEDIQNWHKQVQKTKQESEAEKASQIIPLKTGG
  
Inhibitor
Name:
BDBM50370587
Synonyms:
CEFAZOLIN
Type:
Small organic molecule
Emp. Form.:
C14H14N8O4S3
Mol. Mass.:
454.507
SMILES:
Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn2cnnn2)C3=O)C(O)=O)s1 |r,t:7|
Structure:
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