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Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ligand
BDBM50497028
Substrate
n/a
Meas. Tech.
ChEMBL_1335027 (CHEMBL3239458)
Kd
1050±n/a nM
Citation
 Yun, MK; Hoagland, D; Kumar, G; Waddell, MB; Rock, CO; Lee, RE; White, SW The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg Med Chem 22:2157-65 (2014) [PubMed]  Article 
Target
Name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Synonyms:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase | HPPK | HPPK_ECOLI | JW0138 | PPPK | folK
Type:
PROTEIN
Mol. Mass.:
18075.55
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_108237
Residue:
159
Sequence:
MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVALETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMKNRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
  
Inhibitor
Name:
BDBM50497028
Synonyms:
CHEMBL3233217
Type:
Small organic molecule
Emp. Form.:
C7H9N5O2
Mol. Mass.:
195.1787
SMILES:
NC1Nc2ncc(CO)nc2C(O)=N1 |c:13|
Structure:
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