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Target
Proteasome subunit beta type-9
Ligand
BDBM50503685
Substrate
n/a
Meas. Tech.
ChEMBL_1811420 (CHEMBL4310880)
IC50
440±n/a nM
Citation
 Kato, H; El-Desoky, AH; Takeishi, Y; Nehira, T; Angkouw, ED; Mangindaan, REP; de Voogd, NJ; Tsukamoto, S Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens. Bioorg Med Chem Lett 29:8-10 (2019) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-9
Synonyms:
LMP2 | Low molecular mass protein 2 | Macropain chain 7 | Multicatalytic endopeptidase complex chain 7 | PSB9_HUMAN | PSMB6i | PSMB9 | Proteasome chain 7 | Proteasome subunit beta-1i | RING12 | Really interesting new gene 12 protein
Type:
PROTEIN
Mol. Mass.:
23256.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
219
Sequence:
MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
  
Inhibitor
Name:
BDBM50503685
Synonyms:
CHEMBL4092241
Type:
Small organic molecule
Emp. Form.:
C26H42N2
Mol. Mass.:
382.6251
SMILES:
[H][C@]12CN3CC(=C1)[C@]1([H])CCN(C[C@@]1([H])CC\C=C/CCCC3)CCCC\C=C/CC2 |r,c:5,19,30|
Structure:
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