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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50505059
Substrate
n/a
Meas. Tech.
ChEMBL_1817341 (CHEMBL4317001)
Ki
0.020000±n/a nM
Citation
 Wang, X; Blackaby, W; Allen, V; Chan, GKY; Chang, JH; Chiang, PC; Dične, C; Drummond, J; Do, S; Fan, E; Harstad, EB; Hodges, A; Hu, H; Jia, W; Kofie, W; Kolesnikov, A; Lyssikatos, JP; Ly, J; Matteucci, M; Moffat, JG; Munugalavadla, V; Murray, J; Nash, D; Noland, CL; Del Rosario, G; Ross, L; Rouse, C; Sharpe, A; Slaga, D; Sun, M; Tsui, V; Wallweber, H; Yu, SF; Ebens, AJ Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma. J Med Chem 62:2140-2153 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50505059
Synonyms:
CHEMBL4459538
Type:
Small organic molecule
Emp. Form.:
C21H25F2N7O2S
Mol. Mass.:
477.531
SMILES:
CO[C@H]1C[C@H](N)CCN(C1)c1c(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)cnn1C |r|
Structure:
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