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Target
Carbonic anhydrase 14
Ligand
BDBM50117672
Substrate
n/a
Meas. Tech.
ChEMBL_1831757 (CHEMBL4331765)
Ki
39±n/a nM
Citation
 Buemi, MR; Di Fiore, A; De Luca, L; Angeli, A; Mancuso, F; Ferro, S; Monti, SM; Buonanno, M; Russo, E; De Sarro, G; De Simone, G; Supuran, CT; Gitto, R Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety. Eur J Med Chem 163:443-452 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 14
Synonyms:
CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV)
Type:
Enzyme
Mol. Mass.:
37665.67
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme.
Residue:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
  
Inhibitor
Name:
BDBM50117672
Synonyms:
CHEMBL3613783
Type:
Small organic molecule
Emp. Form.:
C16H16N2O3S
Mol. Mass.:
316.375
SMILES:
NS(=O)(=O)c1ccc(cc1)C(=O)N1CCCc2ccccc12
Structure:
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