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Target
Arginase-1
Ligand
BDBM290365
Substrate
n/a
Meas. Tech.
ChEMBL_1837116 (CHEMBL4337249)
IC50
210±n/a nM
Citation
 Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD Discovery of  J Med Chem 62:8164-8177 (2019) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290365
Synonyms:
(1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarboxylic acid | US10098902, Example 1 | US10603330, Example 1 | US11389464, Example 1
Type:
Small organic molecule
Emp. Form.:
C9H18BNO4
Mol. Mass.:
215.055
SMILES:
N[C@]1(CCC[C@@H]1CCCB(O)O)C(O)=O |r|
Structure:
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