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Target
Arginase-1
Ligand
BDBM50511658
Substrate
n/a
Meas. Tech.
ChEMBL_1845399 (CHEMBL4345826)
IC50
98±n/a nM
Citation
 Blaszczyk, R; Brzezinska, J; Dymek, B; Stanczak, PS; Mazurkiewicz, M; Olczak, J; Nowicka, J; Dzwonek, K; Zagozdzon, A; Golab, J; Golebiowski, A Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors. ACS Med Chem Lett 11:433-438 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50511658
Synonyms:
Cb-1158 | INCB-001158 | Incb 001158 | Incb001158 | Numidargistat
Type:
Small organic molecule
Emp. Form.:
C11H22BN3O5
Mol. Mass.:
287.12
SMILES:
C[C@H](N)C(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
Structure:
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