Reaction Details Report a problem with these data
Target
Ribosomal protein S6 kinase alpha-6
Ligand
BDBM50520168
Substrate
n/a
Meas. Tech.
ChEMBL_1879131 (CHEMBL4380525)
IC50
8910±n/a nM
Citation
Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor. J Med Chem 63:601-612 (2020) [PubMed] Article
More Info.:
Target
Name:
Ribosomal protein S6 kinase alpha-6
Synonyms:
90 kDa ribosomal protein S6 kinase 6 | KS6A6_HUMAN | RPS6KA6 | RPS6KA6(Kin.Dom.1 - N-terminal) | RPS6KA6(Kin.Dom.2 - C-terminal) | RSK-4 | RSK4 | Ribosomal S6 Kinase 4 (RSK-4) | Ribosomal S6 kinase 4 | Ribosomal protein S6 kinase alpha 6 | Ribosomal protein S6 kinase alpha 6 (RSK4) | Ribosomal protein S6 kinase alpha-6 | S6K-alpha 6 | p90-RSK 6 | p90RSK | pp90RSK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
83868.06
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
745
Sequence:
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL