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Target
Ribosomal protein S6 kinase alpha-6
Ligand
BDBM50520161
Substrate
n/a
Meas. Tech.
ChEMBL_1879131 (CHEMBL4380525)
IC50
4120±n/a nM
Citation
 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor. J Med Chem 63:601-612 (2020) [PubMed]  Article 
Target
Name:
Ribosomal protein S6 kinase alpha-6
Synonyms:
90 kDa ribosomal protein S6 kinase 6 | KS6A6_HUMAN | RPS6KA6 | RPS6KA6(Kin.Dom.1 - N-terminal) | RPS6KA6(Kin.Dom.2 - C-terminal) | RSK-4 | RSK4 | Ribosomal S6 Kinase 4 (RSK-4) | Ribosomal S6 kinase 4 | Ribosomal protein S6 kinase alpha 6 | Ribosomal protein S6 kinase alpha 6 (RSK4) | Ribosomal protein S6 kinase alpha-6 | S6K-alpha 6 | p90-RSK 6 | p90RSK | pp90RSK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
83868.06
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
745
Sequence:
MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKRTSTGL
  
Inhibitor
Name:
BDBM50520161
Synonyms:
CHEMBL4468020 | US10894784, Example 39.01.02
Type:
Small organic molecule
Emp. Form.:
C27H29F3N8O
Mol. Mass.:
538.5674
SMILES:
FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cnn(CC4CC4)c3)c2)CC1
Structure:
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