Reaction Details Report a problem with these data
Target
Somatostatin receptor type 2
Ligand
BDBM50075290
Substrate
n/a
Meas. Tech.
ChEBML_200682
Ki
4.6±n/a nM
Citation
 Pasternak, A; Pan, Y; Marino, D; Sanderson, PE; Mosley, R; Rohrer, SP; Birzin, ET; Huskey, SE; Jacks, T; Schleim, KD; Cheng, K; Schaeffer, JM; Patchett, AA; Yang, L Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization. Bioorg Med Chem Lett 9:491-6 (1999) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50075290
Synonyms:
(2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3,3-diphenyl-propyl)-2-oxo-imidazolidin-1-yl]-3-(1H-indol-3-yl)-N-methyl-butyramide | CHEMBL344511
Type:
Small organic molecule
Emp. Form.:
C36H43N5O4
Mol. Mass.:
609.7577
SMILES:
C[C@H]([C@@H](N1CCN(CCC(c2ccccc2)c2ccccc2)C1=O)C(=O)N(C)C[C@H]1OC[C@H](N)CO1)c1c[nH]c2ccccc12 |wU:2.2,29.31,wD:32.35,1.0,(-1.21,3.06,;-1.19,1.52,;.15,.76,;1.47,1.53,;1.45,3.07,;4.13,3.1,;4.14,1.56,;5.48,.79,;6.8,1.58,;8.14,.81,;9.47,1.59,;10.8,.83,;12.13,1.6,;12.12,3.14,;10.76,3.9,;9.45,3.12,;8.15,-.73,;6.82,-1.5,;6.84,-3.04,;8.17,-3.81,;9.5,-3.02,;9.48,-1.48,;2.81,.77,;2.82,-.77,;.15,-.78,;1.69,-.78,;-.63,-2.11,;-2.17,-2.08,;.12,-3.44,;-.65,-4.77,;.12,-6.11,;-.67,-7.44,;-2.22,-7.43,;-3,-8.75,;-2.96,-6.07,;-2.19,-4.76,;-2.52,.74,;-2.51,-.79,;-3.84,-1.57,;-5.17,-.8,;-6.51,-1.57,;-7.86,-.8,;-7.86,.74,;-6.51,1.51,;-5.17,.74,)|
Structure:
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