Reaction Details Report a problem with these data
Target
Cytochrome P450 2B6
Ligand
BDBM50240772
Substrate
n/a
Meas. Tech.
ChEMBL_1911034 (CHEMBL4413480)
IC50
>20000±n/a nM
Citation
Graziani, D; Caligari, S; Callegari, E; De Toma, C; Longhi, M; Frigerio, F; Dilernia, R; Menegon, S; Pinzi, L; Pirona, L; Tazzari, V; Valsecchi, AE; Vistoli, G; Rastelli, G; Riva, C Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5. J Med Chem 62:1246-1273 (2019) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 2B6
Synonyms:
CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6)
Type:
Protein
Mol. Mass.:
56289.75
Organism:
Homo sapiens (Human)
Description:
P20813
Residue:
491
Sequence:
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
Inhibitor
Name:
BDBM50240772
Synonyms:
(1R,2S)-(-)-2-phenylcyclopropylamine | (1R,2S)-2-phenylcyclopropanamine | (tranylcypromine)2-Phenyl-cyclopropylamine | 2-Phenyl-cyclopropylamine | CHEMBL1179 | Parnate | TRANYLCYPROMINE | TRANYLCYPROMINE HYDROCHLORIDE | US10836743, Compound TCP | US8993808, Tranylcypromine | US9180183, Tranylcypromine | cid_2723716 | rel-Tranylcypromine
Type:
Small organic molecule
Emp. Form.:
C9H11N
Mol. Mass.:
133.1903
SMILES:
N[C@@H]1C[C@H]1c1ccccc1 |r|