Reaction Details Report a problem with these data
Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50152902
Substrate
n/a
Meas. Tech.
ChEMBL_305667 (CHEMBL827936)
IC50
<1±n/a nM
Citation
Xue, CB; Chen, XT; He, X; Roderick, J; Corbett, RL; Ghavimi, B; Liu, RQ; Covington, MB; Qian, M; Ribadeneira, MD; Vaddi, K; Trzaskos, J; Newton, RC; Duan, JJ; Decicco, CP Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett 14:4453-9 (2004) [PubMed] Article
More Info.:
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
Inhibitor
Name:
BDBM50152902
Synonyms:
CHEMBL185397 | N-Hydroxy-2-{4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylmethyl]-tetrahydro-pyran-4-yl}-acetamide
Type:
Small organic molecule
Emp. Form.:
C25H28N2O6S
Mol. Mass.:
484.565
SMILES:
Cc1cc(COc2ccc(cc2)S(=O)(=O)CC2(CC(=O)NO)CCOCC2)c2ccccc2n1