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Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50195496
Substrate
n/a
Meas. Tech.
ChEMBL_425008 (CHEMBL911428)
IC50
>10000±n/a nM
Citation
 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett 16:6241-5 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-beta-hydroxysteroid dehydrogenase 2 | DHI2_RAT | Hsd11b2 | Hsd11k
Type:
PROTEIN
Mol. Mass.:
43740.05
Organism:
Rattus norvegicus
Description:
ChEMBL_735659
Residue:
400
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
  
Inhibitor
Name:
BDBM50195496
Synonyms:
(4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylpiperidin-1-yl)methanone | CHEMBL222668
Type:
Small organic molecule
Emp. Form.:
C14H18Cl2N2O
Mol. Mass.:
301.212
SMILES:
C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1
Structure:
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