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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50227001
Substrate
n/a
Meas. Tech.
ChEMBL_461466 (CHEMBL927478)
Ki
5±n/a nM
Citation
 Biju, P; Taveras, A; Yu, Y; Zheng, J; Chao, J; Rindgen, D; Jakway, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Qiu, H; Merritt, JR; Baldwin, JJ 3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists. Bioorg Med Chem Lett 18:228-31 (2008) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50227001
Synonyms:
3-{4-[(R)-2,2-dimethyl-1-(5-methyl-furan-2-yl)-propylamino]-1-oxo-1H-1lambda4-[1,2,5]thiadiazol-3-ylamino}-2-hydroxy-N,N-dimethyl-benzamide | CHEMBL403206
Type:
Small organic molecule
Emp. Form.:
C21H27N5O4S
Mol. Mass.:
445.535
SMILES:
CN(C)C(=O)c1cccc(Nc2ns(=O)nc2N[C@@H](c2ccc(C)o2)C(C)(C)C)c1O
Structure:
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