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Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50326398
Substrate
n/a
Meas. Tech.
ChEMBL_657428 (CHEMBL1246404)
Ki
3.20±n/a nM
Citation
 Longshaw, AI; Adanitsch, F; Gutierrez, JA; Evans, GB; Tyler, PC; Schramm, VL Design and synthesis of potent"sulfur-free" transition state analogue inhibitors of 5'-methylthioadenosine nucleosidase and 5'-methylthioadenosine phosphorylase. J Med Chem 53:6730-46 (2010) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50326398
Synonyms:
(+/-)-trans-1-[(9-Deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-ethylpyrrolidin-3-ol | CHEMBL1241349
Type:
Small organic molecule
Emp. Form.:
C13H19N5O
Mol. Mass.:
261.3229
SMILES:
CC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O |r|
Structure:
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