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Target
Phosphodiesterase
Ligand
BDBM15296
Substrate
n/a
Meas. Tech.
ChEMBL_156456 (CHEMBL764834)
IC50
1000±n/a nM
Citation
Nomoto, Y; Takai, H; Ohno, T; Nagashima, K; Yao, K; Yamada, K; Kubo, K; Ichimura, M; Mihara, A; Kase, H Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232). J Med Chem 39:297-303 (1996) [PubMed] Article
More Info.:
Target
Name:
Phosphodiesterase
Synonyms:
Heart phosphodiesterase | Phosphodiesterase 3B
Type:
PROTEIN
Mol. Mass.:
124301.20
Organism:
Bos taurus
Description:
ChEMBL_156453
Residue:
1115
Sequence:
MRRDERDAKAMRSPPPPDGAASPPESVRNGYVKGCVSPLRQDPPRGFFFHLCRFCNVELLLPPPASPQQPRRGSPFSRARLLLGALAAFVLALLLGSGPESWAAGAARLRTLLSVCSQSLSPLFSIACAFFFLTCFLTRTKRGAGPGRSGGGSWWLLALPACCYLGDFLVGQWESWSRGDGDARAPVPHTPPAVAGRWFLVLSCVGLLTLAQPGRLRHSIVVLLFSSFVWWVSFTSLGALPPALRPLLSCLVGGVGCLLALGLDHFFQIREAPQQPQLSSTAEEKVPVIRPRRRSSCVSFGETSGGYYGSCKMFRRPSLPCISREQMILWDWDLKQWYKPHYQISGGGSGVDLSVLNEARNMVSDLLVDPTLPPQVIASLRSISSLMGAFSGSCRPKMNPLTPFPGFYPCSEIEDPAEKGDRKLHKGLNSRNSLPTPHLRRSSGTSGLPPIDQTSPRWERNNGKRPHQEFGILSQGCYLNGPFSSNLLTVPKQRSSSVSLTHHVGLRRAGGLPSMNSPSHGPVSAGSPANRSPIEFPDTAEFLTKPPVILHKSLSSTPNSPDFYQQLRNSDSNLCNSCGHQILKYDSASEPESGTDCHREKSGGEDNTVFSKASFNLTEAQQEVETENRDGRKLLWEGENHLKAAAQNEEQPNIEQEASQDLILIEDYDSLIENMSNWNFQIFELVEKMGEKSGRILSQVVYTLFQDTGLLEIFKIPTLQFMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTRPIPGLQEIHSDHGAGNETAINPERIAYISSRSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWTLYLSRPEYNFLLNLDNVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPTKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIESEEDDDTESCYEEEDAEELDTEDEEIEDNLNSKPQRRKGRRQIFCQLMHHLTENHKIWKEIIEEEEKCKADGNKLQMENSSLPQGDEIQVIEEADEEEERQLE
Inhibitor
Name:
BDBM15296
Synonyms:
6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carbonitrile | 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile | CHEMBL189 | Milrinone | Primacor | US9242982, Milrinone | US9249139, Milrinone
Type:
Small organic molecule
Emp. Form.:
C12H9N3O
Mol. Mass.:
211.2194
SMILES:
Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N