Reaction Details Report a problem with these data
Target
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Ligand
BDBM50214606
Substrate
n/a
Meas. Tech.
ChEMBL_459090 (CHEMBL926258)
IC50
15±n/a nM
Citation
 Bruno, RD; Njar, VC Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem 15:5047-60 (2007) [PubMed]  Article 
Target
Name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1
Type:
Protein
Mol. Mass.:
58889.66
Organism:
Homo sapiens (Human)
Description:
Q07973
Residue:
514
Sequence:
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
  
Inhibitor
Name:
BDBM50214606
Synonyms:
4'-chloro-biphenyl-4-carboxylic acid (2-imidazol-1-yl-2-phenyl-ethyl)-amide | Azole, 12 | CHEMBL253613
Type:
Small organic molecule
Emp. Form.:
C24H20ClN3O
Mol. Mass.:
401.888
SMILES:
Clc1ccc(cc1)-c1ccc(cc1)C(=O)NCC(c1ccccc1)n1ccnc1 |w:17.18|
Structure:
Search PDB for entries with ligand similarity: