Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM17636
Substrate
n/a
Meas. Tech.
ChEMBL_477728 (CHEMBL927026)
pH
4.4±n/a
IC50
2900±n/a nM
Comments
extracted
Citation
 Julius, RL; Farha, OK; Chiang, J; Perry, LJ; Hawthorne, MF Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores. Proc Natl Acad Sci U S A 104:4808-13 (2007) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM17636
Synonyms:
2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid | Arlef | CHEMBL23588 | Flufenamic acid | Nichisedan | US20240002326, Compound Flufenamic acid | US9271961, Flufenamic Acid
Type:
Small organic molecule
Emp. Form.:
C14H10F3NO2
Mol. Mass.:
281.2299
SMILES:
OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
Structure:
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