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Target
Carnitine O-palmitoyltransferase 1, muscle isoform
Ligand
BDBM50403028
Substrate
n/a
Meas. Tech.
ChEMBL_887375 (CHEMBL2216984)
IC50
360±n/a nM
Citation
 Ceccarelli, SM; Chomienne, O; Gubler, M; Arduini, A Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research. J Med Chem 54:3109-52 (2011) [PubMed]  Article 
Target
Name:
Carnitine O-palmitoyltransferase 1, muscle isoform
Synonyms:
CPT I | CPT1-M | CPT1B | CPT1B_HUMAN | CPTI-M | Carnitine O-palmitoyltransferase I, muscle isoform | Carnitine palmitoyltransferase I-like protein | KIAA1670
Type:
PROTEIN
Mol. Mass.:
87823.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_887440
Residue:
772
Sequence:
MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRIKNGILRGVYPGSPTSWLVVIMATVGSSFCNVDISLGLVSCIQRCLPQGCGPYQTPQTRALLSMAIFSTGVWVTGIFFFRQTLKLLLCYHGWMFEMHGKTSNLTRIWAMCIRLLSSRHPMLYSFQTSLPKLPVPRVSATIQRYLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNTDVQAARLGNIIHAMIMYRRKLDREEIKPVMALGIVPMCSYQMERMFNTTRIPGKDTDVLQHLSDSRHVAVYHKGRFFKLWLYEGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALDEESYSYDPEDEASLSLYGKALLHGNCYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETGHCLGKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDRGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADLRDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLYLVSKYLGVSSPFLAEVLSEPWRLSTSQIPQSQIRMFDPEQHPNHLGAGGGFGPVADDGYGVSYMIAGENTIFFHISSKFSSSETNAQRFGNHIRKALLDIADLFQVPKAYS
  
Inhibitor
Name:
BDBM50403028
Synonyms:
CHEMBL2216769
Type:
Small organic molecule
Emp. Form.:
C35H58N7O20P3S
Mol. Mass.:
1021.856
SMILES:
CCCCCCCC[C@H]1OC(=O)C(CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2OP(O)(O)=O)n2cnc3c(N)cnnc23)[C@@H]1C(O)=O |r|
Structure:
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