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Target
Kynurenine--oxoglutarate transaminase 3
Ligand
BDBM50386310
Substrate
n/a
Meas. Tech.
ChEMBL_939752 (CHEMBL2329105)
IC50
6400±n/a nM
Citation
 Tuttle, JB; Anderson, M; Bechle, BM; Campbell, BM; Chang, C; Dounay, AB; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Horner, W; James, LC; Kim, JY; McAllister, LA; Pandit, J; Parikh, VD; Rago, BJ; Salafia, MA; Strick, CA; Zawadzke, LE; Verhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett 4:37-40 (2013) [PubMed]  Article 
Target
Name:
Kynurenine--oxoglutarate transaminase 3
Synonyms:
CCBL2 | Cysteine-S-conjugate beta-lyase 2 | KAT3 | KAT3_HUMAN | KATIII | KYAT3 | Kynurenine aminotransferase III | Kynurenine--glyoxylate transaminase | Kynurenine--oxoglutarate transaminase III
Type:
PROTEIN
Mol. Mass.:
51406.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_939752
Residue:
454
Sequence:
MFLAQRSLCSLSGRAKFLKTISSSKILGFSTSAKMSLKFTNAKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDLSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSETKSQFEKFVRFCFIKKDSTLDAAEEIIKAWSVQKS
  
Inhibitor
Name:
BDBM50386310
Synonyms:
CHEMBL2049092
Type:
Small organic molecule
Emp. Form.:
C10H12N2O3
Mol. Mass.:
208.2139
SMILES:
COc1ccc2C[C@H](N)C(=O)N(O)c2c1 |r|
Structure:
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