Reaction Details
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Gamma-aminobutyric acid receptor subunit rho-1
Ligand
BDBM50032955
Substrate
n/a
Meas. Tech.
ChEMBL_1456653 (CHEMBL3370253)
EC50
39000±n/a nM
Citation
Petersen, JG; Sørensen, T; Damgaard, M; Nielsen, B; Jensen, AA; Balle, T; Bergmann, R; Frølund, B Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists. Eur J Med Chem 84:404-16 (2014) [PubMed] Article More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit rho-1
Synonyms:
GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
55892.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456653
Residue:
479
Sequence:
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Inhibitor
Name:
BDBM50032955
Synonyms:
1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,2,3,6-tetrahydropyridine-4-carboxylic acid | 1,2,3,6-tetrahydropyridinium-4-carboxylate | CHEMBL39071 | Isoguvacine
Type:
Small organic molecule
Emp. Form.:
C6H9NO2
Mol. Mass.:
127.1412
SMILES:
OC(=O)C1=CCNCC1 |t:3|
Structure:
