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Target
High affinity choline transporter 1
Ligand
BDBM87576
Substrate
n/a
Meas. Tech.
ChEMBL_1464243 (CHEMBL3404110)
IC50
600±n/a nM
Citation
 Bollinger, SR; Engers, DW; Ennis, EA; Wright, J; Locuson, CW; Lindsley, CW; Blakely, RD; Hopkins, CR Synthesis and structure-activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter. Bioorg Med Chem Lett 25:1757-60 (2015) [PubMed]  Article 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1
Type:
PROTEIN
Mol. Mass.:
63194.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1464247
Residue:
580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM87576
Synonyms:
MLS001100779 | N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-(1-propan-2-ylpiperidin-4-yl)oxy-benzamide | N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-(1-propan-2-ylpiperidin-4-yl)oxybenzamide | N-[(3-ethyl-5-isoxazolyl)methyl]-4-methoxy-3-[(1-propan-2-yl-4-piperidinyl)oxy]benzamide | N-[(3-ethylisoxazol-5-yl)methyl]-3-[(1-isopropyl-4-piperidyl)oxy]-4-methoxy-benzamide | SMR000658847 | cid_24793407
Type:
Small organic molecule
Emp. Form.:
C22H31N3O4
Mol. Mass.:
401.4992
SMILES:
CCc1cc(CNC(=O)c2ccc(OC)c(OC3CCN(CC3)C(C)C)c2)on1
Structure:
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