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TargetTyrosyl-DNA phosphodiesterase 2
LigandBDBM50179250
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1582562
IC50 3500±n/a nM
Citation Kossmann, BRAbdelmalak, MLopez, STender, GYan, CPommier, YMarchand, CIvanov, I Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett26:3232-3236 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosyl-DNA phosphodiesterase 2
Name:Tyrosyl-DNA phosphodiesterase 2
Synonyms:5''''''''-Tyr-DNA phosphodiesterase | 5''''''''-tyrosyl-DNA phosphodiesterase | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:Enzyme Catalytic Domain
Mol. Mass.:40916.54
Organism:Homo sapiens (Human)
Description:gi_23510348
Residue:362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50179250
NameBDBM50179250
Synonyms:CHEMBL3813826
TypeSmall organic molecule
Emp. Form.C23H19N5O6S
Mol. Mass.493.492
SMILESOC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O |t:3|
Structure
n/a