Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 1
Ligand
BDBM82472
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_456
Citation
 Kennett, GA; Bright, F; Trail, B; Baxter, GS; Blackburn, TP Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol 117:1443-8 (1996) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 1
Synonyms:
Adrenaline alpha1 | Oct1 | Organic cation transporter 1 | S22A1_RAT | Slc22a1 | Solute carrier family 22 member 1 | adrenergic Alpha1 | rOCT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
61538.40
Organism:
RAT
Description:
Adrenaline alpha1 0 RAT::Q63089
Residue:
556
Sequence:
MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGKSSST
  
Inhibitor
Name:
BDBM82472
Synonyms:
BW-723C86 | CAS_5311036 | NSC_5311036
Type:
Small organic molecule
Emp. Form.:
C16H18N2OS
Mol. Mass.:
286.392
SMILES:
CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12
Structure:
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