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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50176062
Substrate
n/a
Ki
19.6±n/a nM
Comments
PDSP_1542
Citation
 Tatsumi, M; Groshan, K; Blakely, RD; Richelson, E Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-58 (1997) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50176062
Synonyms:
3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine | 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine | 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene | 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene | CHEMBL668 | N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine | N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine | PROTRIPTYLINE | amimetilina
Type:
Small organic molecule
Emp. Form.:
C19H21N
Mol. Mass.:
263.3767
SMILES:
CNCCCC1c2ccccc2C=Cc2ccccc12 |c:13|
Structure:
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