Reaction Details
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Alpha-2A adrenergic receptor
Ligand
BDBM34572
Substrate
n/a
Ki
43.65±n/a nM
Comments
PDSP_1943
Citation
Jasper, JR; Lesnick, JD; Chang, LK; Yamanishi, SS; Chang, TK; Hsu, SA; Daunt, DA; Bonhaus, DW; Eglen, RM Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol 55:1035-43 (1998) [PubMed] Article More Info.:
Target
Name:
Alpha-2A adrenergic receptor
Synonyms:
ADRA2A | Alpha-2A adrenergic receptor | adrenergic Alpha2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48888.08
Organism:
MOUSE
Description:
adrenergic Alpha2A ADRA2A MOUSE::Q01338
Residue:
450
Sequence:
MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKGKTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Inhibitor
Name:
BDBM34572
Synonyms:
BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058355 | UK 14,304 | cid_2435
Type:
Small organic molecule
Emp. Form.:
C11H10BrN5
Mol. Mass.:
292.135
SMILES:
Brc1c(NC2=NCCN2)ccc2nccnc12 |t:4|
Structure:
