Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM87078
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM87078
Synonyms:
3-(4-aminophenyl)-3-(2,5-dimethyl-1-pyrrolyl)propanoic acid ethyl ester | 3-(4-aminophenyl)-3-(2,5-dimethylpyrrol-1-yl)propionic acid ethyl ester | MLS-0288593.0001 | cid_3822568 | ethyl 3-(4-aminophenyl)-3-(2,5-dimethylpyrrol-1-yl)propanoate
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2
Mol. Mass.:
286.3688
SMILES:
CCOC(=O)CC(c1ccc(N)cc1)n1c(C)ccc1C
Structure:
