Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87287
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
19744±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87287
Synonyms:
1-(2-chloranyl-5-morpholin-4-ylsulfonyl-phenyl)-3-[(E)-1-(2-fluorophenyl)ethylideneamino]thiourea | 1-(2-chloro-5-morpholin-4-ylsulfonylphenyl)-3-[(E)-1-(2-fluorophenyl)ethylideneamino]thiourea | 1-(2-chloro-5-morpholinosulfonyl-phenyl)-3-[(E)-1-(2-fluorophenyl)ethylideneamino]thiourea | 1-[2-chloro-5-(4-morpholinylsulfonyl)phenyl]-3-[(E)-1-(2-fluorophenyl)ethylideneamino]thiourea | MLS000374577 | SMR000244192 | cid_9640836
Type:
Small organic molecule
Emp. Form.:
C19H20ClFN4O3S2
Mol. Mass.:
470.969
SMILES:
CC(=NNC(=S)Nc1cc(ccc1Cl)S(=O)(=O)N1CCOCC1)c1ccccc1F |w:2.2|
Structure:
Search PDB for entries with ligand similarity: