Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87326
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
17164±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87326
Synonyms:
1-[4-(7-chloranylquinolin-4-yl)piperazin-1-yl]propan-1-one | 1-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]-1-propanone | 1-[4-(7-chloro-4-quinolyl)piperazino]propan-1-one | 1-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propan-1-one | 1-[4-(7-chloroquinolin-4-yl)piperazino]propan-1-one | MLS000860931 | SMR000459715 | cid_2823727
Type:
Small organic molecule
Emp. Form.:
C16H18ClN3O
Mol. Mass.:
303.787
SMILES:
CCC(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: